The Laboratory for Modeling and Scientific Computing (MOX) conducts cutting-edge interdisciplinary research in mathematical modeling, numerical analysis, applied statistics, and computational science, and their application to problems in Applied Science and Engineering, aimed at addressing society's grand challenges.

The FDS laboratory is a structure devoted to communication between university and the outside world. In particular, it designs and implements programs aimed at consolidating student preparation, advanced courses for teacher training, experimentation with innovative didactic techniques (e.g. MOOCs), and research in the field of Mathematics Education. It also carries out an intense scientific dissemination activity for the communication of mathematical and scientific culture and, more generally, activities aimed at deepening and disseminating the existing relationships between mathematics and all other cultural areas.

Qfinlab is the Quantitative Finance laboratory of the Department of Mathematics at the Politecnico di Milano. Its activities encompass not only the publication of scientific articles in prestigious journals but also extend to the development of financial education programs (https://www.imparalafinanza.it) and outreach initiatives aimed at professionals in the financial and insurance sectors (https://www.finriskalert.it, https://www.esgcorporatedata.it).

The laboratory FoQuS aims to foster research activities in the conceptual and mathematical features of quantum physics. As such, it offers a common platform to address foundational, interpretational, theoretical and formal issues in quantum mechanics, quantum field theory and quantum gravity, with the aim to enforce research exchange across different scientific-disciplinary sectors present within the Mathematics Department. In doing so, it even purports to develop external collaborations with colleagues in other departments of PoliMi as well as with national and international scholars working on quantum physics around the world. FoQuS is also committed to contribute to the improvement of the quality of education of quantum physics at the academic level as well as of the models and methods based on it.